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6 Major Prescribed and Off-Label Uses of Modafinil

    Ever since it’s discovery in 1976 in France, Modafinil has evolved, becoming the world’s first and only safe smart drug. It is currently available across the globe, and its usage has changed from initial treatment of narcolepsy to many others, including being an effective cognitive enhancer. The global acclamation that the drug enjoys is due to its effectiveness in keeping users awake, alert and in optimal state of mind. Numerous studies have been conducted that have proved its magical treatment abilities. Discussed herein are six major uses of Modafinil today.

    1. Treatment of Narcolepsy

    Narcolepsy is a neurological condition that is characterized by disrupted sleep and wakefulness. It usually leads to extreme sleepiness during the day and in serious cases, can even lead to fainting or long hours of sleepiness during the day. There is no known cause of this condition which has been around for ages, but studies have associated it with genetic factors and the absence of neurons in the brains responsible for the release of orexin.

    Numerous studies on the effectiveness of Modafinil in the treatment of narcolepsy have been positive. Patients suffering from the condition have reported improvements in scores when the Maintenance of Wakefulness Test and Multiple Sleep Latency Tests are conducted. The same studies have established that the drug doesn’t affect sleep at night, if used accordingly.

    To confirm the drug’s efficiency, patients who discontinue the drug have experienced the return of narcolepsy-related symptoms. Unlike other stimulants such as amphetamines where users experience some withdrawal symptoms, such cases are rare with Modafinil. However, there are some common side effects such as headaches. To cushion patients from serious side effects, users are encouraged to seek a doctor’s attention as soon as they detect any side effects. Health experts recommend the drug as the primary remedy for narcolepsy.

    1. Shift-Work Disorder

    Productivity at work cannot be compromised. Most people have to take up two or more jobs to fend for their families. Working in shifts can be demanding and even drain the mind. This can be risky for handlers of complex machinery because exhaustion can set in and result in avoidable accidents. Shift-work sleep disorder is a condition that is associated with working odd hours when one should actually be sleeping, especially at night. Some employees may work for longer hours, stretching their body and mind beyond the limits.

    Working in shifts can result in either extreme daytime sleepiness or total lack of sleep during the day. The danger of not sleeping during the day is that, sleep will try to sneak it at night during the shift. It can be assumed that the body, with time, will adapt to the sleeping pattern, but this is not always the case. Studies have shown that Modafinil immensely reduces attention lapses at work. The United States Food and Drugs Administration (FDA) approved the use of the drug for the treatment of this condition in 2003, just 5 years after approving its use for the treatment of narcolepsy on prescription. Online pharmacies sell generic Modafinil as Modalert, which is approved as a strictly prescription-based drug in the US.

    1. Obstructive Sleep Apnea/Hypopnea Syndrome(OSAHS)

    This is a relatively serious sleeping conditions that is characterized by breathing difficulties while sleeping. Apnea is when there is a complete blockage of the airway while hypopnea syndrome refers to partial obstruction of the airway. People suffering from apnea, normally experience symptoms such as loud snoring, choking, sore throats, dry mouth, excessive daytime sleepiness and headaches in the morning. Modafinil is recommended for the correction of apnea and hypopnea. It is worth pointing out that it is not a sure treatment for the condition but rather a remedy to enhance daytime sleepiness that is associated with inability to sleep at night.

    1. Attention Deficit/Hyperactivity Disorder (ADHD)

    This is an off-label use of Modafinil that is equally popular mainly as a result of the stimulating effect the drug has on the body. Users have testified that the drug enables them to remain attentive and alert longer, boosting the ability to execute tasks better and with the precision. Most reviewers laud the drug because it lacks serious side effects such as depression and anxiety that are associated with other medicine. In fact, studies have shown that the medication is a suitable alternative to traditional stimulants used to treat ADHD in adults. Use of the drug in children with ADHD is, however, discouraged even though studies have indicated that it is relatively safe and efficient remedy.

    1. Depression

    Life can be difficult to most people. Loved ones are lost. People are laid off from work when they least expect. Some have loved ones in hospital beds and others are dealing with divorce. All these challenges, if not addressed well, can plunge one into serious depression. Sleeping becomes a problem, and that can affect one’s ability to be productive at work. Studies have shown that people who only partially or don’t respond to traditional antidepressants respond well, they use Modafinil. Furthermore, multiple sclerosis which mainly characterized by fatigue can as well be improved by taking the medication.

    1. Improved Cognitive Functions

    Brain health care is key for productivity. Modafinil is currently one of the best nootropic drugs used to enhance cognitive functions. Actually, it made its way into the Wall Street ages ago(you require a sharp mind to work in the banking and stock exchange market). University students and astronauts use the drug to boost the brain power. Studies have shown a relationship between Modafinil and memory, especially in tackling complex problems. This makes it ideal for students preparing for complex examinations and jobseekers preparing for interviews. Other studies have shown that students who use Modafinil improve in their performance compared to those who don’t. This is attributed to the fact that the drug enhances cognitive abilities of the users, leading to precise responses to intricate questions.


    While there are some scientifically-proven uses and benefits of Modafinil, it is important to note that the other off-label uses are not approved in most countries. Furthermore, research and findings on the effectiveness of the drug when used for the aforementioned is non-conclusive and still ongoing. To safeguard yourself from possible side effects, you are encouraged to talk to your doctor before using. Always buy from safe pharmacies like to ensure the delivery of highest quality of medicines.